Protegemos tu salud a través de la Ciencia
Investigación
Evaluación de riesgo
Líneas de investigación
Contenidos con Investigacion .
Evaluación de riesgo
La unidad colabora y proporciona asesoramiento científico-técnico a diversas organizaciones internacionales, como la European Partnership for Alternative Approaches to Animal Testing (EPAA), la Organización de las Naciones Unidas para la Alimentación y la Agricultura (FAO) y la Unión Internacional de Química Pura y Aplicada (IUPAC). Además de realizar evaluaciones de riesgo regulatorias de sustancias químicas, estamos involucrados en proyectos de investigación que desarrollan nuevas metodologías de evaluación de riesgo. Las líneas de investigación incluyen el desarrollo, utilización e implementación de:
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- “Integrated Approaches to Testing and Assessment (IATAs)” para evaluar de manera integral los riesgos de las sustancias químicas, combinando diferentes fuentes de datos y evidencia, como datos in vitro, in silico y estudios en animales.
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- “Adverse Outcome Pathways (AOPs)” y redes AOPs para comprender mejor los mecanismos moleculares y biológicos que conducen a los efectos adversos en la salud humana y el medio ambiente como resultado de la exposición a sustancias químicas.
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- Métodos de evaluación de riesgos probabilísticos que tienen en cuenta la variabilidad inherente en los datos y las incertidumbres asociadas con los procesos de evaluación. La interpretación de resultados y series de datos existentes nos permite obtener un valor añadido en términos de efectos sobre la salud, humana o ambiental, así como la integración de diferentes fuentes de información.
Publicaciones destacadas
HBM4EU combines and harmonises human biomonitoring data across the EU, building on existing capacity – The HBM4EU survey
Gilles L, Govarts E, Rambaud L, Vogel N, Castano A, Esteban Lopez M, Rodriguez Martin L, Koppen G, Remy S, Vrijheid M, Montazeri P, Birks L, Sepai O, Stewart L, Fiddicke U, Loots I, Knudsen LB, Kolossa-Gehring M, Schoeters G. HBM4EU combines and harmonises human biomonitoring data across the EU, building on existing capacity – The HBM4EU survey. Int J Hyg Environ Health 237. 2021.
DOIToxicity of nanoplastics for zebrafish embryos, what we know and where to go next
Torres-Ruiz M, De la Vieja A, De Alba González M, Esteban López M, Castaño A, Cañas A. Toxicity of nanoplastics for zebrafish embryos, what we know and where to go next. Sci Total Environ 797. 2021.
DOICritical review of analytical methods for the determination of flame retardants in human matrices
Parvaneh H, Castaño A, Cequier E, Covaci A, Esteban López M, Gonzalez Antuña A, Haug LS, Henríquez-Hernández LA, Melymuk L, Pérez Luzardo O, Thomsen C, Vorkamp K. Critical review of analytical methods for the determination of flame retardants in human matrices. Anal Chim Acta.
DOIInterlaboratory Comparison Investigations (ICIs) and External Quality Assurance Schemes (EQUASs) for Flame Retardant Analysis in Biological Matrices: Results from the HBM4EU Project
Dvorakova D, Pulkrabova J, Gramblicka T, Polachova A, Buresova M, Hajslova J, Esteban López M, Castaño A, Nübler S, Haji-Abbas-Zarrabi K, Klausner N, Göen T, Mol H, Koch HM, Vaccher V, Antignac JP, Småstuen Haug L, Vorkamp K. Interlaboratory Comparison Investigations (ICIs) and External Quality Assurance Schemes (EQUASs) for Flame Retardant Analysis in Biological Matrices: Results from the HBM4EU Project. Environ Res 202. 2021.
DOISocio-Demographic Health Determinants Are Associated with Poor Prognosis in Spanish Patients Hospitalized with COVID-19
Martín-Sánchez J, Valls Carbó A, Miró O, Llorens P, Jiménez S, Piñera P, Burillo-Putze G, Martín A, García-Lamberechts JE, Jacob J, Alquézar A, Martínez-Valero C, Miranda J de D, López Picado A, Arrebola JP, Esteban López M, Parviainen A, González del Castillo J, on behalf of the Spanish Social-Environmental COVID-19. Socio-Demographic Health Determinants Are Associated with Poor Prognosis in Spanish Patients Hospitalized with COVID-19. J Gen Intern Med. 2021.
DOIThe European human biomonitoring platform - Design and implementation of a laboratory quality assurance/quality control (QA/QC) programme for selected priority chemicals
Esteban López M, Göen T, Mol H, Nübler S, Haji-Abbas-Zarrabi K, Koch MH, , Kasper-Sonnenberg M, Dvorakova D, Hajslova J, Antignac JP, Vaccher V, Elbers I, Thomsen C, Vorkamp K, Pedraza – Díaz S, Kolossa-Gehring M, Castaño A. The European human biomonitoring platform - Design and implementation of a laboratory quality assurance/quality control (QA/QC) programme for selected priority chemicals. Int J Hyg Environ Health. 234. 2021.
DOIInterlaboratory comparison investigations (ICI) and external quality assurance schemes (EQUAS) for cadmium in urine and blood: Results from the HBM4EU project
Nübler S, Esteban López M, Castaño A, Mol H, Schäfer M, Haji-Abbas-Zarrabi K, Bury D, Koch HM, Vaccher V, Antignac JP, Dvorakova D, Hajslova J, Thomsen C, Vorkamp K, Göen T. Interlaboratory comparison investigations (ICI) and external quality assurance schemes (EQUAS) for cadmium in urine and blood: Results from the HBM4EU project. Int J Hyg Environ Health. 234. 2021.
DOITowards harmonized criteria in Quality Assurance and Quality Control of suspect and non-target LC-HRMS analytical workflows for screening of emerging contaminants in human biomonitoring
Caballero-Casero N, Belova L, Vervliet P, Antignac JP, Castaño A, Debrauwer L, Esteban López M, Huber C, Klanova J, Krauss M, Lommen A, Mol HGJ, Oberacher H, Pardo O, Price EJ, Reinstadler V, Vitale CM, van Nuijs ALN, Covaci A. Towards harmonized criteria in Quality Assurance and Quality Control of suspect and non-target LC-HRMS analytical workflows for screening of emerging contaminants in human biomonitoring. TrAC 136. 2021.
DOITowards harmonized biobanking for biomonitoring: a comparison of human biomonitoring-related and clinical biorepositories
Lermen D, Gwinner F, Bartel-Steinbach M, Mueller SC, Habermann JK, Balwir MB, Smits E, Virgolino A, Fiddicke U, Berglund M, Akesson A, Bergstrom A, Leander K, Horvat M, Snoj Tratnik J, Posada de la Paz M, Castaño A, Esteban López M, von Briesen H, Zimmermann H, and Kolossa-Gehring M. Towards harmonized biobanking for biomonitoring: a comparison of human biomonitoring-related and clinical biorepositories. Biopreserv biobank 18:122-135. 2020.
DOIMercury levels in blood, urine and hair in a nation-wide sample of Spanish adults
Castaño A, Pedraza-Díaz S, Cañas AI, Pérez-Gómez B, Ramos JJ, Bartolomé M, Pärt P, Soto EP, Motas M, Navarro N, Calvo E, Esteban M. Mercury levels in blood, urine and hair in a nation-wide sample of Spanish adults. Sci Tot Environ 670: 262–270. 2019.
DOIMothers and children are related, even in exposure to chemicals present in common consumer products
Koppen G, Govarts E, Vanermen G, Voorspoels S, Govindan M, Dewolf MC, Den Hond E, Biote P, Casteleyn L, Kolossa-Gehring M, Schwedler G, Angerer J, Koch HM, Schindler BK., Castaño A, Esteban López M, Sepai O, Exley K, Bloemen L, Knudsen LE, Joas R, Joas A, Schoeters G Covaci A. Mothers and children are related, even in exposure to chemicals present in common consumer products. Environ Res 175: 297–307. 2019.
DOIAssociations of multiple exposures to persistent toxic substances with the risk of hyperuricemia and subclinical uric acid levels in BIOAMBIENT.ES study
Arrebola JP, Ramos JJ, Bartolomé M, Esteban M, Huetos O, Cañas AI, López-Herranz A, Calvo E, Pérez-Gómez B, Castaño A, BIOAMBIENT.ES. Associations of multiple exposures to persistent toxic substances with the risk of hyperuricemia and subclinical uric acid levels in BIOAMBIENT.ES study. Environ Int. 123: 512–521. 2019.
DOIDifferential contribution of animal and vegetable food items on persistent organic pollutant serum concentrations in Spanish adults
Arrebola JP, Castaño A, Esteban M, Bartolomé M, Pérez – Gómez B, Ramos JJ, BIOAMBIENT.ES. Differential contribution of animal and vegetable food items on persistent organic pollutant serum concentrations in Spanish adults. Data from BIOAMBIENT.ES project. Sci Tot Environ. 364: 235 – 242. 2018.
DOIA review of human biomonitoring in selected Southeast Asian countries
Barnett - Itzhaki Z, Esteban López M, Puttaswamy N, Berman T. A review of human biomonitoring in selected Southeast Asian countries. Environ Int. 116:165-164. 2018.
DOIUrinary phthalate concentrations in mothers and their children in Ireland: results of the DEMOCOPHES human biomonitoring study
Cullen E, Evans D, Griffin C, Burke P, Mannion R, Burns D, Flanagan A, Kellegher A, Schoeters G, Govarts E, Biot P, Casteleyn L, Castaño A, Kolossa-Gehring M, Esteban M, Schwedler G, Koch H, Angerer J, Knudsen L, Joas R, Joas A, Dumez B, Sepai O, Exley K, Aerts D. Urinary phthalate concentrations in mothers and their children in Ireland: results of the DEMOCOPHES human biomonitoring study. Int J Environ Res Public Health. 14: 1456. 2017.
DOIPerfluorinated alkyl substances in Spanish adults: Geographical distribution and determinants of exposure
Bartolomé M, Gallego-Picó A, Cutanda F, Huetos O, Esteban M, Pérez-Gómez B, Bioambient.es, Castaño A. Perfluorinated alkyl substances in Spanish adults: Geographical distribution and determinants of exposure. Sci Total Environ. 603-604: 352-360. 2017.
DOIHuman biomonitoring pilot study DEMOCOPHES in Germany: Contribution to a harmonized European approach
Schwedler G, Seiwert M, Fiddicke U, Ißleb S, Hölzer J, Nendza J, Wilhelm M, Wittsiepe J, Koch HM, Schindler BK, Göen T, Hildebrand J, Joas R, Joas A, Casteleyn L, Angerer J, Castano A, Esteban M, Schoeters G, Den Hond E, Sepai O, Exley K, Bloemen L, Knudsen LE, Kolossa-Gehring M. Human biomonitoring pilot study DEMOCOPHES in Germany: Contribution to a harmonized European approach. Int J Hyg Environ Health. 220:686-696. 2017.
DOIOrganochlorinated pesticides levels in a representative sample of the Spanish adult population: the BIOAMBIENT.ES project
Ramos J.J., Huetos O., González S., Esteban M., Calvo E., Pérez-Gómez B., Castaño A. Organochlorinated pesticides levels in a representative sample of the Spanish adult population: the BIOAMBIENT.ES project. Int J Hyg Environ Health. 220: 217-226. 2017.
DOIDemocophes Hu – A Human Biomonitoring Study for the Assessment of Environmental Exposures of School-Aged Children and their Mothers in Hungary
Középesy S, Kovács K, Náray M, Tóth E, Csaja T, Frankó E, 4, Kovács A, János Varró M, Den Hond E, Govarts E, Willems H, Smolders R, Casteleyn L , Kolossa-Gehring M, Schwedler G, Castaño A, Esteban M, et al. Democophes Hu – A Human Biomonitoring Study for the Assessment of Environmental Exposures of School-Aged Children and their Mothers in Hungary. Central European Journal of Occupational and Environmental Medicine. 23: 191. 2017.
Mercury analysis in hair: Comparability and quality assessment within the transnational COPHES/DEMOCOPHES project
Esteban M, Schindler BK, Jiménez-Guerrero JA, Koch HM, Angerer J, Rosado M, Rivas TC, Gómez S, Casteleyn L, Kolossa-Gehring, M, Becker K, Bloemen L, Schoeters G, Den Hond E, Sepai O, Exley K, Horvat M, Knudsen LE, Joas A, Joas R, Aerts D, Biot D, Borošová D, Davidson F, Dumitrascu I, Fischer ME, Grander M, Janasik B, Jones K, Kašparová L, Larssen T, Naray M, Nielsen F, Hohenblum P, Pinto R, Pirard C, Plateel G, Tratnik JS, Wittsiepe J, Castaño A, EQUAS Reference Laboratories. Mercury analysis in hair: Comparability and quality assessment within the transnational COPHES/DEMOCOPHES project. Res. 141:24-30. 2015.
DOIDEMOCOPHES España y su contribución a la armonización de la Biovigilancia Humana en Europa
Esteban M, López E, Rodríguez C, Posada M, Castaño A. DEMOCOPHES España y su contribución a la armonización de la Biovigilancia Humana en Europa. Nutr Hosp. 32:394-402.2015.
DOICadmium levels in a representative sample of the Spanish adult population: the BIOAMBIENT.ES project
López-Herranz A, Cutanda F, Esteban M, Pollán M, Calvo E, Pérez-Gómez B, Cortes MV, BIOAMBIENT.ES, Castaño A. Cadmium levels in a representative sample of the Spanish adult population: the BIOAMBIENT.ES project. J Expo Sci Environ Epidemiol. 1-10. 2015.
DOIFish consumption patterns and hair mercury levels in children and their mothers in 17 EU countries
Castaño A, Cutanda F, Esteban M, Pärt P, Navarro C, Gómez S, Rosado M, López A, López E, Exley K, Schindler BK, Govarts E, Casteleyn L, Kolossa-Gehring M, Fiddicke U, Koch H , Angerer J, Den Hond E, Schoeters G, Sepai O, Horvat M, Knudsen LE , Aerts D, Joas A, Biot P, Joas R, Jiménez-Guerrero JA, Díaz G, Pirard C, Katsonouri A, Cerna M, Gutleb AC, Ligocka D, Reis FM, Berglund M, Lupsa IR, Halzlová K, Charlier C, Cullen E, Hadjipanayis A, Krsková A, Jensen JF, Nielsen JK, Schwedler G, Wilhelm W, Rudnai P, Középesy S, Davidson F, Fischer ME, Janasik B, Namorado S , Gurzau AE, Jajcaj M, Mazej D, Tratnik JS, Larsson K, Lehmann A, Crettaz P, Lavranos G, Posada M. Fish consumption patterns and hair mercury levels in children and their mothers in 17 EU countries. Environ Res. 141: 58-68. 2015.
DOIUrinary polycyclic aromatic hydrocarbon metabolites levels in a representative sample of the Spanish adult population: the BIOAMBIENT.ES project
Bartolomé M, Ramos JJ, Cutanda F, Huetos O, Esteban M, Ruiz-Moraga M, Calvo E, Pérez-Gómez B, González O, Castaño A. Urinary polycyclic aromatic hydrocarbon metabolites levels in a representative sample of the Spanish adult population: the BIOAMBIENT.ES project. Chemosphere 135:436-446. 2015.
DOIUrinary levels of eight phthalates metabolites and bisphenol A in mother – child pairs from two Spanish locations
Cutanda F, Koch HM, Esteban M, Sánchez J, Angerer J, Castaño A. Urinary levels of eight phthalates metabolites and bisphenol A in mother – child pairs from two Spanish locations. Int J Hyg Environ Health. 218: 47–57. 2015.
DOIAnti-smoking legislation and its effects on urinary cotinine and cadmium
Sánchez-Rodríguez JE, Bartolomé M, Cañas AI, Huetos O, Navarro C, Rodríguez AC, Arribas M, Esteban M, López A, Castaño A. Anti-smoking legislation and its effects on urinary cotinine and cadmium. Environ Res. 136:227–233. 2015.
DOIHarmonized European human biomonitoring in small countries: Challenges, opportunities and lessons learned in Cyprus and Luxembourg from the DEMOCOPHES study
Katsonouri A, Fischer ME, Hadjipanayis A, Arendt M, Lavranos G, Hoffman L, Maurer-Chronakis K, Guignard C, Fragopoulou C, Cocco E, Anastasi E, Pilavakis D, Efstathiou E, Demetriou L, Hadjiefthychiou A, Demetriou E, Aerts D, Casteleyn L, Biot P, Kolossa-Gehring M, Den Hond E, Schoeters G, Castaño A, Esteban M, Fiddicke U, Exley K, Sepai O, Gutleb AC. Harmonized European human biomonitoring in small countries: Challenges, opportunities and lessons learned in Cyprus and Luxembourg from the DEMOCOPHES study. Biomonitoring. 2:2300-4606. 2015.
DOIUrinary cotinine levels and environmental tobacco smoke in mothers and children of Romania, Portugal and Poland within the European human biomonitoring pilot study
Lupsa IR, Nunes B, Ligocka D, Gurzau AE, Jabkubowski M, Casteleyn L, Aerts D, Biot P, Den Hond E, Castaño C, Esteban M, Kolossa-Gehring M, Fiddicke U, Knudsen LE, Schoeters G, Reis MF. Urinary cotinine levels and environmental tobacco smoke in mothers and children of Romania, Portugal and Poland within the European human biomonitoring pilot study. Environ Res. 141: 106–117. 2015.
DOIThe First steps towards harmonised human biomonitoring in Europe: Demonstration Project to Perform Human Biomonitoring on a European Scale
Den Hond E, Govarts E, Willems H, Smolders R, Casteleyn L, Kolossa – Gehring M, Schwedler G, Seiwert M, Fiddicke U, Castaño A, Esteban M, Angerer J, Koch HM, Schindler BK Sepai O, Exley K, Bloemen L, Horvat M, Knudsen LE, Joas A, Joas R, Biot P, Aerts D, Koppen G, Katsonouri A, Hadjipanayi A, Krskova A, Maly M, Mørck TA, Rudnai P, Kozepesy S, Mulcahy M, Mannion R, Gutleb AC, Fischer ME, Ligocka D, Jakubowski J, Reis MF, Namorado S, GurzauAE, Lupsa IR, Halzlova K, Jajcaj M, Mazej D, Tratnik JS, López A, López E, Berglund M, Larsson K, Lehmann A,Crettaz P, choeters G. The First steps towards harmonised human biomonitoring in Europe: Demonstration Project to Perform Human Biomonitoring on a European Scale. Environ Health Perspect. 123:255-263.2015.
DOICase study: Possible differences in phthalates exposure among the Czech, Hungarian, and Slovak populations identified based on the DEMOCOPHES pilot study results
Černá M, Malý M, Rudnai P, Középesy S, Náray M, Halzlová K, Jajcaj M, Grafnetterová A, Krsková A, Antošová D, Forysová K, Hond ED, Schoeters G, Joas R, Casteleyn L, Joas A, Biot P, Aerts D, Angerer J, Bloemen L, Castaño A, Esteban M, Koch HM, Kolossa-Gehring M, Gutleb AC, Pavloušková J, Vrbík K. Case study: Possible differences in phthalates exposure among the Czech, Hungarian, and Slovak populations identified based on the DEMOCOPHES pilot study results. Environ Res. 141:118-124. 2015.
DOICommunication in a human biomonitoring study: focus group work, public engagement and lessons learnt in 17 European countries
Exley K, Cano N, Aerts D, Biot P, Casteleyn L, Kolossa-Gehring M, Schwedler G, Castaño A, Angerer J, Koch HK, Esteban M, Schoeters G, Den Hond E, Horvat M, Bloemen L, Knudsen LE, Joas R, Joas A, Dewolf MC, Van de Mieroop E, Katsonouri A, Hadjipanayis A, Cerna M, Krskova A, Becker K, Fiddicke U, Seiwert M, Mørck TA, Rudnai P, Kozepesy S, Cullen E, Kellegher A, Gutleb AC, Fischer ME, Ligocka D, Kamińska J, Namorado S, Reis MF, Lupsa I-R, Gurzau AE, Halzlova K, Jajcaj M, Mazej D, Tratnik JS, Huetos O, López A, Berglund M, Larsson K, Sepai O. Communication in a human biomonitoring study: focus group work, public engagement and lessons learnt in 17 European countries. Environ Res. 141:31-41. 2015.
DOIPilot study testing a European human biomonitoring framework for biomarkers of chemical exposure in children and their mothers: experiences in the UK
Exley K, Aerts D, Biot P,CasteleynL, Kolossa-Gehring M, Schwedler G, Castaño A, Angerer J, Koch HM, Esteban M, Schindler BK, Schoeters G, Den Hond G, Horvat M, Bloemen L, Knudsen LE, Joas R, Joas A, Sepai O. Pilot study testing a European human biomonitoring framework for biomarkers of chemical exposure in children and their mothers: experiences in the UK. Sci Pollut Res. 2015.
DOIA pilot study on the feasibility of European harmonized human biomonitoring: strategies towards a common approach, challenges and opportunities.
Casteleyn L, Dumez B, Becker K, Kolossa-Gehring M, Den Hond E, Schoeters G, Castaño A, Koch HM, Angerer J, Esteban M, Exley K, Sepai O, Bloemen L, Horvat M, Knudsen LE, Joas A, Joas R, Biot P, Koppen G, Dewolf M-C, Katsonouri A ,Hadjipanayism A, Cerná M, Krsková A, Schwedler G, Fiddicke U, Nielsen JKS, Jensen JF, Rudnai P, Közepésy S, Mulcahy M, Mannion R, Gutleb AC, Fischer ME, Ligocka D, Jakubowski M, Reis MF, Namorado S, Lupsa I-R, Gurzau AE, Halzlova K, Jajcaj M, Mazej D, Tratnik Snoj J, Posada M, López E, Berglund M, Larsson K, Lehmann A, Crettaz P, Aerts D. A pilot study on the feasibility of European harmonized human biomonitoring: strategies towards a common approach, challenges and opportunities. Environ Res. 141:3-14. 2015.
DOIExposure determinants of cadmium in European mothers and their children
Berglund M, Larsson K, Grandér M, Casteleyn L, Kolossa-Gehring M, Schwedler G, Castaño A, Esteban M, Angerer J, Koch HM, Schindler BK, Schoeters G, Smolders R, Exley K, Sepai O, Bloemen L, Horvat M, Knudsen LE, Mørck TA, Joas A, Joas R, Biot P, Aerts D, De Cremer K, Van Overmeire I, Katsonouri A, Hadjipanayis A, Cerna M, Krskova A, Nielsen JKS, Jensen JF, Rudnai P, Kozepesy S, Griffin C, Nesbitt I, Gutleb AC, Fischer ME, Ligocka D, Jakubowski M, Reis MF, Namorado S, Lupsa IR, Gurzau AE, Halzlova K, Jajcaj M, Mazej D, Tratnik JS, López A, Cañas A, Lehmann A, Crettaz P, Den Hond E, Govarts E. Exposure determinants of cadmium in European mothers and their children. Environ Res. 141: 69-76. 2015.
DOIThe Danish contribution to the European DEMOCOPHES project: A description of cadmium, cotinine and mercury levels in Danish mother-child pairs and the perspectives of supplementary sampling and measurements
Mørck TA, Nielsen F, Nielsen JKS, Jensen JF, Hansen PW, Hansen AK, Christoffersen LN, Siersma VD, Larsen IH, Hohlmann LK, Skaanild MT, Frederiksen H, Biot P, Casteleyn L, Kolossa-Gehring M, Schwedler G, Castaño A, Angerer J, Koch HM, Esteban M, Schoeters G Den Hond E, Exley K, Sepai O, Bloemen L, Joas R, Joas A, Fiddicke U, López A, Cañas A, Aerts A, Knudsen LE. The Danish contribution to the European DEMOCOPHES project: A description of cadmium, cotinine and mercury levels in Danish mother-child pairs and the perspectives of supplementary sampling and measurements. Environ Res. 141:96-105. 2015.
DOIPolicy recommendations and cost implications for a more sustainable framework for European human biomonitoring surveys
Joas A, Knudsen LE, Kolossa-Gehring M, Sepai O, Casteleyn L, Schoeters G, Angerer J, Castaño A, Aerts D, Biot P, Horvat M, Bloemen L, Reis MF, Lupsa I-R, Katsonouri A, Cerna M, Berglund M, Crettaz P, Rudnai P, Halzlova K, Mulcahy M, Gutleb AC, Fischer ME, Becher G, Fréry N, Jensen G, Van Vliet L, Koch HM , Den Hond E, Fiddicke U, Esteban M, Exley K , Schwedler G, Seiwert M, Ligocka D, Hohenblum P, Kyrtopoulos S, Botsivali M, De Felip E, Guillou C, Reniero F, Grazuleviciene R, Veidebaum T ,Mørck TA, Nielsen JKS, Jensen JF, Rivas TC, Sánchez J, Koppen G, Smolders R, Kozepesy S, Hadjipanayis A, Krskova A, Mannion R, Jakubowski M, Fucic JA, Pereira-Miguel J, Gurzau AE, Jajcaj M, Mazej D, Tratnik JS, Lehmann A, Larsson K, Dumez B, Joas R. Policy recommendations and cost implications for a more sustainable framework for European human biomonitoring surveys. Environ Res. 141:42-57. 2015.
DOIUrinary BPA measurements in children and mothers from six European member states: Overall results and determinants of exposure
Covaci A, Den Hond E, Geens T, Govarts E, Koppen G, Frederiksen H, Knudsen LE, Mørck TA, Gutleb A, Guignard E, Cocco E, Horvat M, Heath E, Kosjek T, Mazej D, Tratnik JS, Castaño A, Esteban M, Cutanda F,Ramos JJ, Berglund M, Larsson K, Jönsson BAG, Biot P, Casteleyn L, Joas R, Joas A, Bloemen L, Sepai O, Exley K, Schoeters G, Angerer J, Kolossa-Gehring M, Fiddicke U, Aerts D, Koch HM. Urinary BPA measurements in children and mothers from six European member states: Overall results and determinants of exposure. Environ Res. 141: 77-85. 2015.
DOIInterpreting biomarker data from the COPHES/DEMOCOPHES twin projects: using external exposure data to understand biomarker differences among countries
Smolders R, Den Hond E, Koppen G, Govarts E, Willems H, Casteleyn L, Kolossa-Gehring M, Fiddicke U, Castaño A, Koch HM, Angerer J, Esteban M, Sepai O, Exley K, Bloemen L, Horvat M, Knudsen LE, Joas A, Joas R, Biot P, Aerts D, Katsonouri A, Hadjipanayis A, Cerna M, Krskova A, Schwedler G, Seiwert M, Nielsen JKS, Rudnai P, Közepesy S, Evans DS, Ryan MP, Gutleb AC, Fischer ME, Ligocka D, Jakubowski M, Reis MF, Namorado S, Lupsa I-R, Gurzau AE, Halzlova K, Fabianova E, Mazej D, Tratnik JS, Gómez S, González S, Berglund M, Larsson K, Lehmann A, Crettaz P, Schoeters G. Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects: using external exposure data to understand biomarker differences among countries. Environ Res. 141:86-95. 2015.
DOILessons learnt on recruitment and fieldwork from a pilot European human biomonitoring survey
Fiddicke U, Becker K, Schwedler G, Seiwert M, Joas R, Joas A, Biot P, Aerts D, Casteleyn L, Dumez B, Castaño A, Esteban M, Angerer J, Koch HM, Schoeters G, Den Hond E, Sepai O, Exley K, Knudsen LE, Horvat M, Bloemen L, Katsonouri A, Hadjipanayis A, Cerna M, Krsková A, Jensen JF, Nielsen JKS, Rudnai P, Közepésy S, Gutleb AC, Fischer ME, Ligocka D, KaminskaJ, Reis MF, Namorado S, Lupsa IR, Gurzau AE, Halzlova K, Mazej D, Tratnik JS, Rivas TC,Gómez S, Berglund M, Larsson K, Lehmann A, Crettaz P, Dewolf MC, Burns D, Kellegher A, Kolossa-Gehring M. Lessons learnt on recruitment and fieldwork from a pilot European human biomonitoring survey. Environ Res. 141:15-23. 2015.
DOIMercury exposure in Ireland: Results of the DEMOCOPHES human biomonitoring study
Cullen E, Evans D, Davidson F, Burke P, Flanagan A, Griffin C, Kellegher A, Mannion R, Mulcahy M, Ryan M, Biot P, Casteleyn L, Castaño A, Angerer J, Koch HM, Esteban M, Schindler BK, Navarro C, Kolossa-Gehring M, Fiddicke U, Schoeters G, Den Hond E, Sepai O, Exley O, Bloemen L, Knudsen LE, Joas R, Joas A, Aerts D. Mercury exposure in Ireland: Results of the DEMOCOPHES human biomonitoring study. Int J Environ ResPublic Health. 11: 9760-9775. 2014.
DOISerum PCB levels in a representative sample of the Spanish adult population: The BIOAMBIENT.ES project
Huetos O, Bartolomé M, Aragonés N, Cervantes-Amat M, Esteban M, Ruíz-Moraga M, Pérez-Gómez B, Calvo E, Vila M, BIOAMBIENT.ES, Castaño A. Serum PCB levels in a representative sample of the Spanish adult population: The BIOAMBIENT.ES project. Sci Total Environ. 493: 834-844. 2014.
DOIThe European COPHES/DEMOCOPHES project: Towards transnational comparability and reliability of human biomonitoring results
Schindler BK, Esteban M, Koch HM, Castaño A, Koslitz S, Cañas A, Casteleyn L, Kolossa-Gehring M, Schwedler G, Schoeters G, Den Hond E, Sepai O, Exley K, Bloemen L, Horvat M, Knudsen LE, Joas A, Joas R, Biot P, Aerts D, López A, Huetos O, Katsonourin A, Maurer-Chronakis K, Kasparova L, Vrbík K, Rudnai P, Naray M, Guignard C, Fischer ME, Ligocka D, Janasik B, Reis MF Namorado S, Pop C, Dumitrascu I, Halzlova K, Fabianova E, Mazejj D, Tratnik JS, Berglund M, Jönsson B, Lehmann A, Crettaz P, Frederiksen H, Nielsen F, McGrath H, Nesbitt I, De Cremer K, Vanermen G, Koppen G, Wilhelm M, Becker K, Angerer J. The European COPHES/DEMOCOPHES project: Towards transnational comparability and reliability of human biomonitoring results. Int J Hyg Environ Health. 217: 653-661. 2014.
DOI. Blood lead levels in a representative sample of the Spanish adult population: The BIOAMBIENT.ES project
Cañas AI, Cervantes-Amat M, Esteban M, Ruiz-Moraga M, Pérez-Gómez B, Mayor J, Castaño A, BIOAMBIENT.ES. Blood lead levels in a representative sample of the Spanish adult population: The BIOAMBIENT.ES project. Int J Hyg Environ Health. 217:452-459. 2014.
DOIHair mercury and urinary cadmium levels in Belgian children and their mothers within the framework of the COPHES/DEMOCOPHES projects
Pirard C, Koppen G, De Cremer K, Van Overmeire I, Govarts E, Dewolf MC, Van De Mieroop E, Aerts D, Biot P, Casteleyn L, Kolossa-Gehring M, Schwedler G, Angerer J, Koch HM, Schindler BK, Castaño A, Esteban M, Schoeters G, Den Hond E, Sepai O, Exley K, Horvat M, Bloemen L, Knudsen LE, Joas R, Joas A, Van Loco J, Charlier C. Hair mercury and urinary cadmium levels in Belgian children and their mothers within the framework of the COPHES/DEMOCOPHES projects. Sci Total Environ. 472:730-740. 2014.
DOIA systematic approach for designing a HBM Pilot Study for Europe
Becker K, Seiwert M, Casteleyn L, Joas R, Joas A, Biot P, Aerts D, Castaño A, Esteban M, Angerer J Koch HM, Schoeters G, Den Hond E, Sepai O, Exley K, Knudsen LE, Horvat M, Bloemen L, Kolossa-Gehring M, DEMOCOPHES consortium. A systematic approach for designing a HBM Pilot Study for Europe. Int J Hyg Environ Health. 217: 312-322. 2014.
DOIEconomic benefits of methylmercury exposure control in Europe: Monetary value of neurotoxicity prevention
Bellanger M, Pichery C, Aerts D, Berglund M, Castaño A, Cejchanova M, Crettaz P, Davidson F, Esteban M, Fischer ME, Gurzau AE, Halzlova K, Katsonouri A, Knudsen LE, Kolossa-Gehring M, Koppen G, Ligocka D, Miklavčič A, Reis MF, Rudnai P, Tratnik JS, Weihe P, Budtz-Jørgensen E, Grandjean P, DEMO/COPHES. Economic benefits of methylmercury exposure control in Europe: Monetary value of neurotoxicity prevention. Environ Health. 12:3. 2013.
DOIRisk of overestimation of urinary cadmium concentrations: interference from molybdenum
Cañas A, Esteban M, Cutanda F, Castaño A. Risk of overestimation of urinary cadmium concentrations: interference from molybdenum. ICHMET 2012 Conference proceedings. E3S Web of Conferences 1, 21003. 2013.
DOIBIOAMBIENT.ES study protocol: rationale and design of a cross-sectional human biomonitoring survey in Spain
Pérez- Gómez B, Pastor-Barriuso R, Cervantes-Amat M, Esteban M, Ruíz-Moraga M, Aragonés N, Pollán M, Navarro C, Calvo E, Román J, López-Abente G, Castaño A on behalf of BIOAMBIENT.ES. BIOAMBIENT.ES study protocol: rationale and design of a cross-sectional human biomonitoring survey in Spain. Environ Sci Pollut Res. 20: 1193-1202. 2013.
DOIAspectos prácticos de la fase pre-analítica del estudio de biovigilancia BIOAMBIENT.ES
Esteban M, Ruiz-Moraga M, Pérez-Gómez B, Castaño A y demás componentes del grupo BIOAMBIENT.ES. Aspectos prácticos de la fase pre-analítica del estudio de biovigilancia BIOAMBIENT.ES. Gac Sanit. 27: 77-80. 2012.
DOIMercury, lead and cadmium levels in the urine of 170 Spanish adults: A pilot human biomonitoring study
Castaño A, Sánchez-Rodríguez J E, Cañas A, Esteban M, Navarro C, Rodríguez-García AC, Arribas M, Díaz G, Jiménez-Guerrero JA. Mercury, lead and cadmium levels in the urine of 170 Spanish adults: A pilot human biomonitoring study. Int J Hyg Environ Health.215: 191-195. 2012.
DOINon-invasive matrices in human biomonitoring: A review
Esteban M, Castaño A. Non-invasive matrices in human biomonitoring: A review. Environ Int. 35:438-449. 2009.
DOIBiomarkers, matrices and analytical methods targeting human exposure to chemicals selected for a European human biomonitoring initiative
Vorkamp K, Castaño A, Antignac JP, Boada LD, Cequier E, Covaci A, Esteban López M, Haug LS, Kasper-Sonnenberg M, Koch HM, Pérez Luzardo O, Osite A, Rambaud L, Pinorini MT, Sabbioni G, Thomsen C. Biomarkers, matrices and analytical methods targeting human exposure to chemicals selected for a European human biomonitoring initiative. Environ Int 146. 2020.
DOILearning from previous work and finding synergies in the domains of public and environmental health: EU-funded projects BRIDGE Health and HBM4EU
David M, Schweler G, Reiber L, Tolonen H, Andersson AM, Esteban López M, Joas A, Schöpel M, Kolossa – Gehring M. Learning from previous work and finding synergies in the domains of public and environmental health: EU-funded projects BRIDGE Health and HBM4EU. Arch Public Health 78. 2020.
DOIShort-Term Ozone Exposure and Daily Mortality in Suburban and Rural Areas of Southern Europe
Maria Angela Doronzo; José Ramón Martinez Fernandez; Diana Gómez-Barroso; María Alonso-Colón; Beatriz Nuñez-Corcuera; Rebeca Ramis Atmosphere 2025-05-20 DOI: 10.3390/atmos16050625
DOIDifferent Ras isoforms regulate synaptic plasticity in opposite directions
López-Merino E, Fernández-Rodrigo A, Jiang JG, Gutiérrez-Eisman S, Fernández de Sevilla D, Fernández-Medarde A, Santos E, Guerra C, Barbacid M, Esteban JA, Briz V. EMBO J. 2025 Feb 21.
DOIEffects of 700 and 3500 MHz 5G radiofrequency exposure on developing zebrafish embryos.
Torres-Ruiz, M.; Suárez, O. J.; López, V.; Marina, P.; Sanchis, A.; Liste, I.; De Alba, M.; Ramos, V., Effects of 700 and 3500 MHz 5G radiofrequency exposure on developing zebrafish embryos. Sci Total Environ 2024, 915, 169475.
DOIA methodological framework for estimating ambient PM2.5 particulate matter concentrations in the UK. Journal of Environmental Sciences, 150, 676-691. Q1
David Galán-Madruga, Parya Broomandi, Alfredo Satyanaga, Ali Jahanbakhsi, Mehdi Bagheri, et al (2025).
DOIUrban environmental noise and depression causal pathway: Potential role of chronic conditions as mediator
Enrique Sanz Olea; Jesus León Hernández; Begoña Artíñano; Verónica Briz; Spyros Karakitsios; Dimosthenis Sarigiannis; Saul García Dos Santos; Beatriz Nuñez-Corcuera; Rebeca Ramis PLOS ONE 2025-05-07 DOI: 10.1371/journal.pone.0322874 Part of ISSN: 1932-6203
DOIImproving air pollution source apportionment in size-segregated PM using Pb isotope-based Bayesian mixing models in Tarragona (Spain)
Edson Plasencia Sánchez, Mònica Rosell, Clara Torrentó, Francisco Sánchez-Soberón, Joaquim Rovira, Jordi Sierra, Marta Schuhmacher, Albert Soler, David Widory (2025). Improving air pollution source apportionment in size-segregated PM using Pb isotope-based Bayesian mixing models in Tarragona (Spain). Atmospheric Research, 316, 107939.
DOIEnhanced mGluR5 intracellular activity causes psychiatric alterations in Niemann Pick type C disease
Ana Toledano-Zaragoza, Violeta Enriquez-Zarralanga, Sara Naya-Forcano, Víctor Briz, Rocío Alfaro-Ruíz, Miguel Parra-Martínez, Daniel N. Mitroi, Rafael Luján, José A. Esteban & María Dolores Ledesma. Enhanced mGluR5 intracellular activity causes psychiatric alterations in Niemann Pick type C disease. Cell Death and Disease (2024) 15:771.
DOIContenidos con Investigacion .
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José Vicente Tarazona Lafarga
Jefe de Grupo. Profesor de Investigación de OPI
Código ORCID: 0000-0003-4920-3055
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La Unidad de Evaluación de Riesgo se creó como una unidad horizontal del CNSA en octubre de 2022, aprovechando la experiencia de investigadores del centro en evaluación de riesgos de plaguicidas y otras sustancias químicas, y la incorporación de nuevos investigadores. Nuestra misión es proporcionar una evaluación científica rigurosa y objetiva de los riesgos que las sustancias químicas pueden representar para las personas y el medio ambiente en diversas condiciones de exposición, en el marco de la aproximación “One Health”. La unidad ofrece a las diferentes Áreas del CNSA, así como a otros grupos del ISCIII interesados, una plataforma o “Laboratorio de Ideas” para obtener un valor añadido a sus resultados, mediante metodologías innovadoras de evaluación de riesgos.