Protegemos tu salud a través de la Ciencia
Investigación
Interacciones genético-ambientales en los trastornos del neurodesarrollo
Líneas de investigación
Content with Investigacion .
Interacciones genético-ambientales en los trastornos del neurodesarrollo
- Modelos celulares in vitro y ex vivo de rasopatías, tales como células madre pluripotenciales, células madre neurales, cultivos primarios neuronales y cultivos organotípicos de rodajas de hipocampo, para estudiar el neurodesarrollo.
- Modelos animales de ratón con mutaciones en las proteínas Ras asociadas a los trastornos de neurodesarrollo (rasopatías) para estudiar la conducta animal relacionada con dichos trastornos, como el desarrollo motor, el comportamiento social y las habilidades cognitivas como la memoria y el aprendizaje.
Proyectos de investigación
Content with Investigacion .
2024-2027 Ministerio de Ciencia e Innovación, Generación de conocimiento, PID2022-136932OB-I00, “Interacciones genético-ambientales como factor de riesgo en la disfunción sináptica asociada a las rasopatías”. IP: Victor Briz (ISCIII). Financiación: 162.500€.
2023-2028 Ministerio de Ciencia e Innovación, Ayuda Ramón y Cajal, RYC2021-031395-I, “Gene-environment interactions as risk factor for neurodevelopmental and cognitive disorders”. IP: Victor Briz (ISCIII). Financiación: 236.350€.
Publicaciones destacadas
Effects of 700 and 3500 MHz 5G radiofrequency exposure on developing zebrafish embryos.
Torres-Ruiz, M; Oscar J. Suárez; Victoria López; Pablo Marina; Aránzazu Sanchis; Isabel Liste; Mercedes de Alba; Victoria Ramos. 2024. Effects of 700 and 3500 MHz 5G radiofrequency exposure on developing zebrafish embryos. Science of the Total Environment. 169475.
DOIInternalization and toxicity of polystyrene nanoplastics on immortalized human neural stem cells
Mª. Carmen González-Caballero; Mercedes de Alba González; Mónica Torres-Ruiz; Ana I. Cañas-Portilla; Patricia Iglesias-Hernandez. Internalization and toxicity of polystyrene nanoplastics on immortalized human neural stem cells. Chemosphere 29:355:141815 2024.
DOINeurotoxicity and endocrine disruption caused by polystyrene nanoparticles in zebrafish embryo.
Mónica Torres-Ruiz, Mercedes de Alba González, Mónica Morales, Raquel Martin-Folgar, Mª Carmen González, Ana I. Cañas-Portilla*, and Antonio De la Vieja* 2023 Neurotoxicity and endocrine disruption caused by polystyrene nanoparticles in zebrafish embryo. Science of the Total Environment, 2023 May 20;874:162406.
DOIDNA damage and molecular level effects induced by polystyrene (PS) nanoplastics (NPs) after Chironomus riparius (Diptera) larvae
Raquel Martin-Folgar, Celia Sabroso, Ana I. Cañas-Portilla, Mónica Torres-Ruíz, Mª Carmen González-Caballero, Helena Dorado, Ignacio Velasco, Mónica Morales. DNA damage and molecular level effects induced by polystyrene (PS) nanoplastics (NPs) after Chironomus riparius (Diptera) larvae. Chemosphere 346 (2024) 140552
DOIHarmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021).
Govarts E, Gilles L, Rodriguez-Martin L, Santonene T, Apel P, Alvito P, Anastasi E, et al. Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021). Int J Hyg Environ Health. 249.114119. 2023.
DOIA simple method for direct mercury análisis in dried blood spot (DBS) simples for human biomonitoring studies
Gonzalez-Rubio JM, Dominguez-Morueco N, Pedraza-Díaz S, Cañas-Portilla A, Lucena MA, Rodriguez A, Castaño A, Esteban-López M. A simple method for direct mercury análisis in dried blood spot (DBS) simples for human biomonitoring studies. Environ Int. 177. 107958. 2023.
DOIHow to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU
Santonen T, Mahiout S, Alvito P, Apel P, Bessems J, Bil W, Borges T, Bose-O'Reilly S, Buekers J, Cañas Portilla AI, Calvo AC, de Alba González M, Domínguez-Morueco N, López ME, Falnoga I, Gerofke A, Caballero MDCG, Horvat M, Huuskonen P, Kadikis N, Kolossa-Gehring M, Lange R, Louro H, Martins C, Meslin M, Niemann L, Díaz SP, Plichta V, Porras SP, Rousselle C, Scholten B, Silva MJ, Šlejkovec Z, Tratnik JS, Joksić AŠ, Tarazona JV, Uhl M, Van Nieuwenhuyse A, Viegas S, Vinggaard AM, Woutersen M, Schoeters G. How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU. International Journal of Hygiene and Environmental Health. 249. 114139. 2023.
DOIMain achievements from the European Human Biomonitoring Initiative HBM4EU.
Gerofke A, Lange R, Vogel N, Schmidt P, Weber T, David M, Frederiksen H, Baken K, Govarts E, Gilles L, Rodriguez Martin L, Martinsone Z, Santonen T, Schoeters G, Scheringer M, Domínguez-Romero E, Esteban López M, Castaño Calvo A, Koch HM, Apel P, Kolossa-Gehring M. Phthalates and substitute plasticizers: Main achievements from the European Human Biomonitoring Initiative HBM4EU. Int J Hyg Environ Health. 259. 114378. 2024.
PUBMED DOICoordination of chemical analyses under the European Human Biomonitoring Initiative (HBM4EU): Concepts, procedures and lessons learnt.
Vorkamp K, Esteban Lopez M, Gilles L, Göen T, Govarts E, Hajeb P, Katsonouri A, Knudsen LE, Kolossa-Gehring M, Lindh C, Nübler S, Pedraza-Díaz S, Santonen T, Castaño A. Coordination of chemical analyses under the European Human Biomonitoring Initiative (HBM4EU): Concepts, procedures and lessons learnt. Int J Hyg Environ Health.251:114183.2023.
DOICognitive Performance and Organophosphate Flame Retardants Exposure in Children: Evidence from a cross-sectional analysis of two European mother-child cohorts.
Rosolen V, Giordani E, Mariuz M, Parpinel M, Mustieles V, Gilles L, Govarts E, Rodriguez-Martin L, Baken K, Schoeters G, Sepai O, Sovcikova E, Fabelova L, Kohoutek J, Jensen Tk, Covaci A, Roggeman M, Melymuk L, Klanova J, Castaño A, Esteban López M. Cognitive Performance and Organophosphate Flame Retardants Exposure in Children: Evidence from a cross-sectional analysis of two European mother-child cohorts. Toxics. 11. 878. 2023.
PUBMED DOIUrinary phthalate/DINCH metabolites associations with kisspeptin and reproductive hormones in teenagers: A cross-sectional study from the HBM4EU aligned studies
Rodriguez-Carrillo A, Remy S, Koppen G, Wauters N, Mustieles V, Desalegn A, Iszatt N, den Hond E, Verheyen VJ, Fabelova L, Palkovicova Murinova L, Pedraza-Diaz S, Esteban M, Poyatos RM, Govarts E, van Nuijs ALN, Covaci A, Schoeters G, Olea N, Fernandez MF. Urinary phthalate/DINCH metabolites associations with kisspeptin and reproductive hormones in teenagers: A cross-sectional study from the HBM4EU aligned studies. Sci Total Environ. 929:171226
DOIAssociation of exposure to perfluoroalkyl substances (PFAS) and phthalates with thyroid hormones in adolescents from HBM4EU aligned studies.
Rodríguez-Carrillo A, Salamanca-Fernández E, den Hond E, Verheyen VJ, Fábelová L, Murinova LP, Pedraza-Díaz S, Castaño A, García-Lario JV, Remy S, Govarts E, Schoeters G, Olea N, Freire C, Fernández MF. Association of exposure to perfluoroalkyl substances (PFAS) and phthalates with thyroid hormones in adolescents from HBM4EU aligned studies. Environmental Research. 237. 116897. 2023.
DOIAssessment of exposure to pesticide mixtures in five European countries by a harmonized urinary suspect screening approach
Ottenbros I, Lebret E, Huber C, Lommen A, Antignac J-P, Čupr P, Šulc L, Mikeš O, Szigeti T, Középesy S, Martinsone I, Martinsone Z, Akulova L, Pardo O, Fernández SF, Coscollá C, Pedraza-Diaz S, Krauss M, Debrauwer L, Wagner K, Nijssen R, Mol H, Vitale CM, Klanova J, Molina BG, León N, Vermeulen R, Luijten M, Vlaanderen Assessment of exposure to pesticide mixtures in five European countries by a harmonized urinary suspect screening approach. International Journal of Hygiene and Environmental Health. 248. 114105. 2023.
DOIUtilización del método de carbón activo para medidas rápidas de radón en viviendas. Revista de Salud Ambiental
M. E. Veiga Ochoa, L. Sánchez Ramos, I. Panero Frade. Utilización del método de carbón activo para medidas rápidas de radón en viviendas. Revista de Salud Ambiental. 2022; 22(2): 143-149.
DOIEstudio estadístico de la actividad desarrollada en la Unidad de Dosimetría Ambiental y Personal del Servicio de Radioprotección del Centro Nacional de Sanidad Ambiental
C Ruiz Gimeno, J Moracho, L Sánchez, C Ballesteros, P Medina, J Castro. Estudio estadístico de la actividad desarrollada en la Unidad de Dosimetría Ambiental y Personal del Servicio de Radioprotección del Centro Nacional de Sanidad Ambiental. RADIOPROTECCIÓN 84 (2016).
PUBMEDApproaches to mixture risk assessment of PFASs in the European population based on human hazard and biomonitoring data
Bil W, Govarts E, Zeilmaker MJ, Woutersen M, Bessems J, Ma Y, Thomsen C, Haug LS, Lignell S, Gyllenhammar I, Palkovicova Murinova L, Fabelova L, Snoj Tratnik J, Kosjek T, Gabriel C, Sarigiannis D, Pedraza-Diaz S, Esteban-López M, Castaño A, Rambaud L, Riou M, Franken C, Colles A, Vogel N, Kolossa-Gehring M, Halldorsson TI, Uhl M, Schoeters G, Santonen T, Vinggaard AM. Approaches to mixture risk assessment of PFASs in the European population based on human hazard and biomonitoring data. Int J Hyg Environ Health. 247: 114071. 2022.
DOICross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies
Schillemans T, Iszatt N, Remy S, Schoeters G, Fernandez MF, D’Cruz SC, Desalegn A, Haug LS, Lignell S, Lindroos AK, Fabelova L, Palkovicova Murinova L, Kosjek T, Tkalec Z, Gabriel C, Sarigiannis D, Pedraza-Díaz S, Esteban-Lopez M, Castaño A, Rambaud L, Riou M, Pauwels S, Vanlarebeke N, Kolossa-Gehring M, Vogel N, Uhl M, Govarts E, Åkesson A. Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies. Environ Pollut. 316: 120566. 2022.
DOIInterpreting biomonitoring data: Introducing the international human biomonitoring (i-HBM) working Group's health-based guidance value (HB2GV) dashboard
Nakayama SF, St-Amand A, Pollock T, Apel P, Bamai YA, Barr DB, Bessems J, Calafat AM, Castaño A, Covaci A, Duca RC, Faure S, Galea KS, Hays S, Hopf NB, Ito Y, Zare Jeddi M, Kolossa-Gehring M, Kumar E, LaKind JS, Esteban Lopez M, Louro H, Macey K, Makris KC, Melnyk L, Murawski A, Naiman J, Nassif J, Noisel N, Poddalgoda D, Quiros-Alcala L, Rafiee A, Rambaud L, Silva MJ, Ueyama J, Verner MA, Nasution Waras M, Werry K. Interpreting biomonitoring data: Introducing the international human biomonitoring (i-HBM) working Group's health-based guidance value (HB2GV) dashboard. Int J Hyg Environ Health. 247: 114046. 2022.
DOIPFAS levels and determinants of variability in exposure in European teenagers – Results from the HBM4EU aligned studies (2014-2021)
Richterova D, Govarts E, Fabelova L, Rausova K, Rodriguez Martin L, Gilles L, Remy S, Colles A, Rambaud L, Riou M, Gabriel C, Sarigiannis D, Pedraza-Diaz S, Ramos JJ, Kosjek T, Snoj Tratnik J, Lignell S, Gyllenhammar I, Thomsen C, Haug LS, Kolossa-Gehring M, Vogel N, Franken C, Vanlarebeke N, Bruckers L, Stewart L, Sepai O, Schoeters G, Uhl M, Castaño A, Esteban López M, Göen T, Palkovicova Murínova P. PFAS levels and determinants of variability in exposure in European teenagers – Results from the HBM4EU aligned studies (2014-2021). Int J Hyg Environ Heatlh. 247: 114057. 2022.
DOIExternal Quality Assurance Schemes (EQUASs) and Inter-laboratory Comparison Investigations (ICIs) for human biomonitoring of Polycyclic Aromatic Hydrocarbon (PAH) biomarkers in urine as part of the quality assurance programme under HBM4EU
Stefanie N, Esteban López M, Castaño A, Mol H, Müller J, Schäfer M, Haji-Abbas-Zarrabi K, Hajslova J, Pulkrabova J, Göen T, Dvorakova D, Urbancova K, Koch HM, Antignac JP, Sakhi AK, Vorkamp K, Burkhardt T, Scherer M. External Quality Assurance Schemes (EQUASs) and Inter-laboratory Comparison Investigations (ICIs) for human biomonitoring of Polycyclic Aromatic Hydrocarbon (PAH) biomarkers in urine as part of the quality assurance programme under HBM4EU. 2022.
DOIInformación adicional
Nuestro objetivo principal es estudiar las interacciones entre determinados factores genéticos y medioambientales, como son las proteínas Ras y los contaminantes ambientales, como factores de riesgo en los trastornos del neurodesarrollo.
Para ello, emplearemos varias aproximaciones metodológicas, desde la biología molecular y celular a la electrofisiología, la histología y el estudio de la conducta animal.
Nuestra hipótesis es que las condiciones genéticas que favorecen la activación basal de la vía Ras-MAPK (como es el caso de las rasopatías) pueden tener una mayor susceptibilidad a la exposición a contaminantes ambientales.