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Investigación
Interacciones genético-ambientales en los trastornos del neurodesarrollo
Líneas de investigación
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Interacciones genético-ambientales en los trastornos del neurodesarrollo
- Modelos celulares in vitro y ex vivo de rasopatías, tales como células madre pluripotenciales, células madre neurales, cultivos primarios neuronales y cultivos organotípicos de rodajas de hipocampo, para estudiar el neurodesarrollo.
- Modelos animales de ratón con mutaciones en las proteínas Ras asociadas a los trastornos de neurodesarrollo (rasopatías) para estudiar la conducta animal relacionada con dichos trastornos, como el desarrollo motor, el comportamiento social y las habilidades cognitivas como la memoria y el aprendizaje.
Proyectos de investigación
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2024-2027 Ministerio de Ciencia e Innovación, Generación de conocimiento, PID2022-136932OB-I00, “Interacciones genético-ambientales como factor de riesgo en la disfunción sináptica asociada a las rasopatías”. IP: Victor Briz (ISCIII). Financiación: 162.500€.
2023-2028 Ministerio de Ciencia e Innovación, Ayuda Ramón y Cajal, RYC2021-031395-I, “Gene-environment interactions as risk factor for neurodevelopmental and cognitive disorders”. IP: Victor Briz (ISCIII). Financiación: 236.350€.
Publicaciones destacadas
The European human biomonitoring platform - Design and implementation of a laboratory quality assurance/quality control (QA/QC) programme for selected priority chemicals
Esteban López M, Göen T, Mol H, Nübler S, Haji-Abbas-Zarrabi K, Koch MH, , Kasper-Sonnenberg M, Dvorakova D, Hajslova J, Antignac JP, Vaccher V, Elbers I, Thomsen C, Vorkamp K, Pedraza – Díaz S, Kolossa-Gehring M, Castaño A. The European human biomonitoring platform - Design and implementation of a laboratory quality assurance/quality control (QA/QC) programme for selected priority chemicals. Int J Hyg Environ Health. 234. 2021.
DOIInterpreting biomarker data from the COPHES/DEMOCOPHES twin projects: using external exposure data to understand biomarker differences among countries
Smolders R, Den Hond E, Koppen G, Govarts E, Willems H, Casteleyn L, Kolossa-Gehring M, Fiddicke U, Castaño A, Koch HM, Angerer J, Esteban M, Sepai O, Exley K, Bloemen L, Horvat M, Knudsen LE, Joas A, Joas R, Biot P, Aerts D, Katsonouri A, Hadjipanayis A, Cerna M, Krskova A, Schwedler G, Seiwert M, Nielsen JKS, Rudnai P, Közepesy S, Evans DS, Ryan MP, Gutleb AC, Fischer ME, Ligocka D, Jakubowski M, Reis MF, Namorado S, Lupsa I-R, Gurzau AE, Halzlova K, Fabianova E, Mazej D, Tratnik JS, Gómez S, González S, Berglund M, Larsson K, Lehmann A, Crettaz P, Schoeters G. Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects: using external exposure data to understand biomarker differences among countries. Environ Res. 141:86-95. 2015.
DOISerum PCB levels in a representative sample of the Spanish adult population: The BIOAMBIENT.ES project
Huetos O, Bartolomé M, Aragonés N, Cervantes-Amat M, Esteban M, Ruíz-Moraga M, Pérez-Gómez B, Calvo E, Vila M, BIOAMBIENT.ES, Castaño A. Serum PCB levels in a representative sample of the Spanish adult population: The BIOAMBIENT.ES project. Sci Total Environ. 493: 834-844. 2014.
DOIThe European COPHES/DEMOCOPHES project: Towards transnational comparability and reliability of human biomonitoring results
Schindler BK, Esteban M, Koch HM, Castaño A, Koslitz S, Cañas A, Casteleyn L, Kolossa-Gehring M, Schwedler G, Schoeters G, Den Hond E, Sepai O, Exley K, Bloemen L, Horvat M, Knudsen LE, Joas A, Joas R, Biot P, Aerts D, López A, Huetos O, Katsonourin A, Maurer-Chronakis K, Kasparova L, Vrbík K, Rudnai P, Naray M, Guignard C, Fischer ME, Ligocka D, Janasik B, Reis MF Namorado S, Pop C, Dumitrascu I, Halzlova K, Fabianova E, Mazejj D, Tratnik JS, Berglund M, Jönsson B, Lehmann A, Crettaz P, Frederiksen H, Nielsen F, McGrath H, Nesbitt I, De Cremer K, Vanermen G, Koppen G, Wilhelm M, Becker K, Angerer J. The European COPHES/DEMOCOPHES project: Towards transnational comparability and reliability of human biomonitoring results. Int J Hyg Environ Health. 217: 653-661. 2014.
DOIA systematic approach for designing a HBM Pilot Study for Europe
Becker K, Seiwert M, Casteleyn L, Joas R, Joas A, Biot P, Aerts D, Castaño A, Esteban M, Angerer J Koch HM, Schoeters G, Den Hond E, Sepai O, Exley K, Knudsen LE, Horvat M, Bloemen L, Kolossa-Gehring M, DEMOCOPHES consortium. A systematic approach for designing a HBM Pilot Study for Europe. Int J Hyg Environ Health. 217: 312-322. 2014.
DOIMercury levels in blood, urine and hair in a nation-wide sample of Spanish adults
Castaño A, Pedraza-Díaz S, Cañas AI, Pérez-Gómez B, Ramos JJ, Bartolomé M, Pärt P, Soto EP, Motas M, Navarro N, Calvo E, Esteban M. Mercury levels in blood, urine and hair in a nation-wide sample of Spanish adults. Sci Tot Environ 670: 262–270. 2019.
DOIPerfluorinated alkyl substances in Spanish adults: Geographical distribution and determinants of exposure
Bartolomé M, Gallego-Picó A, Cutanda F, Huetos O, Esteban M, Pérez-Gómez B, Bioambient.es, Castaño A. Perfluorinated alkyl substances in Spanish adults: Geographical distribution and determinants of exposure. Sci Total Environ. 603-604: 352-360. 2017.
DOIMercury analysis in hair: Comparability and quality assessment within the transnational COPHES/DEMOCOPHES project
Esteban M, Schindler BK, Jiménez-Guerrero JA, Koch HM, Angerer J, Rosado M, Rivas TC, Gómez S, Casteleyn L, Kolossa-Gehring, M, Becker K, Bloemen L, Schoeters G, Den Hond E, Sepai O, Exley K, Horvat M, Knudsen LE, Joas A, Joas R, Aerts D, Biot D, Borošová D, Davidson F, Dumitrascu I, Fischer ME, Grander M, Janasik B, Jones K, Kašparová L, Larssen T, Naray M, Nielsen F, Hohenblum P, Pinto R, Pirard C, Plateel G, Tratnik JS, Wittsiepe J, Castaño A, EQUAS Reference Laboratories. Mercury analysis in hair: Comparability and quality assessment within the transnational COPHES/DEMOCOPHES project. Res. 141:24-30. 2015.
DOIDEMOCOPHES España y su contribución a la armonización de la Biovigilancia Humana en Europa
Esteban M, López E, Rodríguez C, Posada M, Castaño A. DEMOCOPHES España y su contribución a la armonización de la Biovigilancia Humana en Europa. Nutr Hosp. 32:394-402.2015.
DOIAspectos prácticos de la fase pre-analítica del estudio de biovigilancia BIOAMBIENT.ES
Esteban M, Ruiz-Moraga M, Pérez-Gómez B, Castaño A y demás componentes del grupo BIOAMBIENT.ES. Aspectos prácticos de la fase pre-analítica del estudio de biovigilancia BIOAMBIENT.ES. Gac Sanit. 27: 77-80. 2012.
DOINon-invasive matrices in human biomonitoring: A review
Esteban M, Castaño A. Non-invasive matrices in human biomonitoring: A review. Environ Int. 35:438-449. 2009.
DOIInterlaboratory Comparison Investigations (ICI) for human biomonitoring of chromium as part of the quality assurance programme under HBM4EU
Nübler S, Esteban López M, Castaño A, Mol HGJ, Haji-Abbas-Zarrabi K, Schäfer M, Müller J, Hajslova J, Dvorakova D, Antignac JP, Koch HM, Småstuen Haug L , Vorkamp K, Göen T. Interlaboratory Comparison Investigations (ICIs) and External Quality Assurance Schemes (EQUASs) for human biomonitoring of perfluoroalkyl substances (PFASs) in serum as part of the quality assurance programme under HBM4EU. Science of the Total Environment 847 157481. 2022.
DOIProficiency and Interlaboratory variability in the determination of phthalate and DINCH biomarkers in human urine: results from the HBM4EU project
Mol HGJ, Elbers I, Pälmke C, Bury D, Göen T, Esteban López M, Nübler S, Vaccher V, Antignac JP, Dvořáková D, Hajšlová D, Sakhi AK, Thomsen C, Vorkamp K, Castaño A, Koch HM. Proficiency and Interlaboratory variability in the determination of phthalate and DINCH biomarkers in human urine: results from the HBM4EU project. Toxics 10:57. 2022.
DOIHBM4EU Occupational Biomonitoring Study on e-Waste-Study Protocol
Scheepers PTJ, Duca RC, Galea KS, Godderis L, Hardy E, Knudsen LE, Leese E, LouroH, Mahiout S, Ndaw S, et al. HBM4EU Occupational Biomonitoring Study on e-Waste—Study Protocol. Int J Environ Res Public Health 18. 2021.
DOIToxicity of nanoplastics for zebrafish embryos, what we know and where to go next
Torres-Ruiz M, De la Vieja A, De Alba González M, Esteban López M, Castaño A, Cañas A. Toxicity of nanoplastics for zebrafish embryos, what we know and where to go next. Sci Total Environ 797. 2021.
DOIDifferential contribution of animal and vegetable food items on persistent organic pollutant serum concentrations in Spanish adults
Arrebola JP, Castaño A, Esteban M, Bartolomé M, Pérez – Gómez B, Ramos JJ, BIOAMBIENT.ES. Differential contribution of animal and vegetable food items on persistent organic pollutant serum concentrations in Spanish adults. Data from BIOAMBIENT.ES project. Sci Tot Environ. 364: 235 – 242. 2018.
DOIHuman biomonitoring pilot study DEMOCOPHES in Germany: Contribution to a harmonized European approach
Schwedler G, Seiwert M, Fiddicke U, Ißleb S, Hölzer J, Nendza J, Wilhelm M, Wittsiepe J, Koch HM, Schindler BK, Göen T, Hildebrand J, Joas R, Joas A, Casteleyn L, Angerer J, Castano A, Esteban M, Schoeters G, Den Hond E, Sepai O, Exley K, Bloemen L, Knudsen LE, Kolossa-Gehring M. Human biomonitoring pilot study DEMOCOPHES in Germany: Contribution to a harmonized European approach. Int J Hyg Environ Health. 220:686-696. 2017.
DOICadmium levels in a representative sample of the Spanish adult population: the BIOAMBIENT.ES project
López-Herranz A, Cutanda F, Esteban M, Pollán M, Calvo E, Pérez-Gómez B, Cortes MV, BIOAMBIENT.ES, Castaño A. Cadmium levels in a representative sample of the Spanish adult population: the BIOAMBIENT.ES project. J Expo Sci Environ Epidemiol. 1-10. 2015.
DOIAnti-smoking legislation and its effects on urinary cotinine and cadmium
Sánchez-Rodríguez JE, Bartolomé M, Cañas AI, Huetos O, Navarro C, Rodríguez AC, Arribas M, Esteban M, López A, Castaño A. Anti-smoking legislation and its effects on urinary cotinine and cadmium. Environ Res. 136:227–233. 2015.
DOIHBM4EU combines and harmonises human biomonitoring data across the EU, building on existing capacity – The HBM4EU survey
Gilles L, Govarts E, Rambaud L, Vogel N, Castano A, Esteban Lopez M, Rodriguez Martin L, Koppen G, Remy S, Vrijheid M, Montazeri P, Birks L, Sepai O, Stewart L, Fiddicke U, Loots I, Knudsen LB, Kolossa-Gehring M, Schoeters G. HBM4EU combines and harmonises human biomonitoring data across the EU, building on existing capacity – The HBM4EU survey. Int J Hyg Environ Health 237. 2021.
DOIInformación adicional
Nuestro objetivo principal es estudiar las interacciones entre determinados factores genéticos y medioambientales, como son las proteínas Ras y los contaminantes ambientales, como factores de riesgo en los trastornos del neurodesarrollo.
Para ello, emplearemos varias aproximaciones metodológicas, desde la biología molecular y celular a la electrofisiología, la histología y el estudio de la conducta animal.
Nuestra hipótesis es que las condiciones genéticas que favorecen la activación basal de la vía Ras-MAPK (como es el caso de las rasopatías) pueden tener una mayor susceptibilidad a la exposición a contaminantes ambientales.