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Investigación
Interacciones genético-ambientales en los trastornos del neurodesarrollo
Líneas de investigación
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Interacciones genético-ambientales en los trastornos del neurodesarrollo
- Modelos celulares in vitro y ex vivo de rasopatías, tales como células madre pluripotenciales, células madre neurales, cultivos primarios neuronales y cultivos organotípicos de rodajas de hipocampo, para estudiar el neurodesarrollo.
- Modelos animales de ratón con mutaciones en las proteínas Ras asociadas a los trastornos de neurodesarrollo (rasopatías) para estudiar la conducta animal relacionada con dichos trastornos, como el desarrollo motor, el comportamiento social y las habilidades cognitivas como la memoria y el aprendizaje.
Proyectos de investigación
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2024-2027 Ministerio de Ciencia e Innovación, Generación de conocimiento, PID2022-136932OB-I00, “Interacciones genético-ambientales como factor de riesgo en la disfunción sináptica asociada a las rasopatías”. IP: Victor Briz (ISCIII). Financiación: 162.500€.
2023-2028 Ministerio de Ciencia e Innovación, Ayuda Ramón y Cajal, RYC2021-031395-I, “Gene-environment interactions as risk factor for neurodevelopmental and cognitive disorders”. IP: Victor Briz (ISCIII). Financiación: 236.350€.
Publicaciones destacadas
The Danish contribution to the European DEMOCOPHES project: A description of cadmium, cotinine and mercury levels in Danish mother-child pairs and the perspectives of supplementary sampling and measurements
Mørck TA, Nielsen F, Nielsen JKS, Jensen JF, Hansen PW, Hansen AK, Christoffersen LN, Siersma VD, Larsen IH, Hohlmann LK, Skaanild MT, Frederiksen H, Biot P, Casteleyn L, Kolossa-Gehring M, Schwedler G, Castaño A, Angerer J, Koch HM, Esteban M, Schoeters G Den Hond E, Exley K, Sepai O, Bloemen L, Joas R, Joas A, Fiddicke U, López A, Cañas A, Aerts A, Knudsen LE. The Danish contribution to the European DEMOCOPHES project: A description of cadmium, cotinine and mercury levels in Danish mother-child pairs and the perspectives of supplementary sampling and measurements. Environ Res. 141:96-105. 2015.
DOIPolicy recommendations and cost implications for a more sustainable framework for European human biomonitoring surveys
Joas A, Knudsen LE, Kolossa-Gehring M, Sepai O, Casteleyn L, Schoeters G, Angerer J, Castaño A, Aerts D, Biot P, Horvat M, Bloemen L, Reis MF, Lupsa I-R, Katsonouri A, Cerna M, Berglund M, Crettaz P, Rudnai P, Halzlova K, Mulcahy M, Gutleb AC, Fischer ME, Becher G, Fréry N, Jensen G, Van Vliet L, Koch HM , Den Hond E, Fiddicke U, Esteban M, Exley K , Schwedler G, Seiwert M, Ligocka D, Hohenblum P, Kyrtopoulos S, Botsivali M, De Felip E, Guillou C, Reniero F, Grazuleviciene R, Veidebaum T ,Mørck TA, Nielsen JKS, Jensen JF, Rivas TC, Sánchez J, Koppen G, Smolders R, Kozepesy S, Hadjipanayis A, Krskova A, Mannion R, Jakubowski M, Fucic JA, Pereira-Miguel J, Gurzau AE, Jajcaj M, Mazej D, Tratnik JS, Lehmann A, Larsson K, Dumez B, Joas R. Policy recommendations and cost implications for a more sustainable framework for European human biomonitoring surveys. Environ Res. 141:42-57. 2015.
DOIEuropean interlaboratory comparison investigations (ICI) and external quality assurance schemes (EQUAS) for the analysis of bisphenol A, S and F in human urine: Results from the HBM4EU project
Vaccher V, Esteban López M, Castaño A, Mol H, Haji-Abbas-Zarrab K, Bury D, Koch HM, Dvorakova D, Hajslova J, Nübler S, Sakhi AK, Thomsen C, Vorkamp K, Göen T, Antignac JP. European interlaboratory comparison investigations (ICI) and external quality assurance schemes (EQUAS) for the analysis of bisphenol A, S and F in human urine: Results from the HBM4EU project. Environ Res 210. 2022.
DOIMercury levels in feathers of penguins from the Antarctic peninsula area: geographical and inter-specific differences
Motas M, Jerez S, Esteban M, Valera F, Cuervo JJ, Barbosa A. Mercury levels in feathers of penguins from the Antarctic peninsula area: geographical and inter-specific differences. Int J Environ Res Public Health. 15: 9918. 2021.
DOICritical review of analytical methods for the determination of flame retardants in human matrices
Parvaneh H, Castaño A, Cequier E, Covaci A, Esteban López M, Gonzalez Antuña A, Haug LS, Henríquez-Hernández LA, Melymuk L, Pérez Luzardo O, Thomsen C, Vorkamp K. Critical review of analytical methods for the determination of flame retardants in human matrices. Anal Chim Acta.
DOIAssociations of multiple exposures to persistent toxic substances with the risk of hyperuricemia and subclinical uric acid levels in BIOAMBIENT.ES study
Arrebola JP, Ramos JJ, Bartolomé M, Esteban M, Huetos O, Cañas AI, López-Herranz A, Calvo E, Pérez-Gómez B, Castaño A, BIOAMBIENT.ES. Associations of multiple exposures to persistent toxic substances with the risk of hyperuricemia and subclinical uric acid levels in BIOAMBIENT.ES study. Environ Int. 123: 512–521. 2019.
DOIOrganochlorinated pesticides levels in a representative sample of the Spanish adult population: the BIOAMBIENT.ES project
Ramos J.J., Huetos O., González S., Esteban M., Calvo E., Pérez-Gómez B., Castaño A. Organochlorinated pesticides levels in a representative sample of the Spanish adult population: the BIOAMBIENT.ES project. Int J Hyg Environ Health. 220: 217-226. 2017.
DOIHarmonized European human biomonitoring in small countries: Challenges, opportunities and lessons learned in Cyprus and Luxembourg from the DEMOCOPHES study
Katsonouri A, Fischer ME, Hadjipanayis A, Arendt M, Lavranos G, Hoffman L, Maurer-Chronakis K, Guignard C, Fragopoulou C, Cocco E, Anastasi E, Pilavakis D, Efstathiou E, Demetriou L, Hadjiefthychiou A, Demetriou E, Aerts D, Casteleyn L, Biot P, Kolossa-Gehring M, Den Hond E, Schoeters G, Castaño A, Esteban M, Fiddicke U, Exley K, Sepai O, Gutleb AC. Harmonized European human biomonitoring in small countries: Challenges, opportunities and lessons learned in Cyprus and Luxembourg from the DEMOCOPHES study. Biomonitoring. 2:2300-4606. 2015.
DOIUrinary cotinine levels and environmental tobacco smoke in mothers and children of Romania, Portugal and Poland within the European human biomonitoring pilot study
Lupsa IR, Nunes B, Ligocka D, Gurzau AE, Jabkubowski M, Casteleyn L, Aerts D, Biot P, Den Hond E, Castaño C, Esteban M, Kolossa-Gehring M, Fiddicke U, Knudsen LE, Schoeters G, Reis MF. Urinary cotinine levels and environmental tobacco smoke in mothers and children of Romania, Portugal and Poland within the European human biomonitoring pilot study. Environ Res. 141: 106–117. 2015.
DOIExposure determinants of cadmium in European mothers and their children
Berglund M, Larsson K, Grandér M, Casteleyn L, Kolossa-Gehring M, Schwedler G, Castaño A, Esteban M, Angerer J, Koch HM, Schindler BK, Schoeters G, Smolders R, Exley K, Sepai O, Bloemen L, Horvat M, Knudsen LE, Mørck TA, Joas A, Joas R, Biot P, Aerts D, De Cremer K, Van Overmeire I, Katsonouri A, Hadjipanayis A, Cerna M, Krskova A, Nielsen JKS, Jensen JF, Rudnai P, Kozepesy S, Griffin C, Nesbitt I, Gutleb AC, Fischer ME, Ligocka D, Jakubowski M, Reis MF, Namorado S, Lupsa IR, Gurzau AE, Halzlova K, Jajcaj M, Mazej D, Tratnik JS, López A, Cañas A, Lehmann A, Crettaz P, Den Hond E, Govarts E. Exposure determinants of cadmium in European mothers and their children. Environ Res. 141: 69-76. 2015.
DOIEconomic benefits of methylmercury exposure control in Europe: Monetary value of neurotoxicity prevention
Bellanger M, Pichery C, Aerts D, Berglund M, Castaño A, Cejchanova M, Crettaz P, Davidson F, Esteban M, Fischer ME, Gurzau AE, Halzlova K, Katsonouri A, Knudsen LE, Kolossa-Gehring M, Koppen G, Ligocka D, Miklavčič A, Reis MF, Rudnai P, Tratnik JS, Weihe P, Budtz-Jørgensen E, Grandjean P, DEMO/COPHES. Economic benefits of methylmercury exposure control in Europe: Monetary value of neurotoxicity prevention. Environ Health. 12:3. 2013.
DOIImproving the Risk Assessment of Pesticides through the Integration of Human Biomonitoring and Food Monitoring Data: A Case Study for Chlorpyrifos.
4. Tarazona, J. V., González-Caballero, M. D. C., de Alba-Gonzalez, M., Pedraza-Diaz, S., Cañas, A., Dominguez-Morueco, N., Esteban-López, M., Cattaneo, I., Katsonouri, A., Makris, K. C., Halldorsson, T. I., Olafsdottir, K., Zock, J. P., Dias, J., De Decker, A., Morrens, B., Berman, T., Barnett-Itzhaki, Z., Lindh, C., … Castaño, A. (2022). Improving the Risk Assessment of Pesticides through the Integration of Human Biomonitoring and Food Monitoring Data: A Case Study for Chlorpyrifos. Toxics, 10(6), 313.
DOIEvaluating urban indoor and outdoor PM10-bound organochlorine pesticides. Air quality status and health impact.
7. Galán-Madruga, D., Cárdenas-Escudero, J., Broomandi, P., Cáceres, J. O., & González, M. D. C. (2023). Evaluating urban indoor and outdoor PM10-bound organochlorine pesticides. Air quality status and health impact. Building and Environment, 228, 109818.
DOIInternalization and toxicity of polystyrene nanoplastics on inmortalized human neural stem cells.
8. González-Caballero, M. C., de Alba González, M., Torres-Ruiz, M., Iglesias-Hernández, P., Zapata, V., Terrón, M. C., Sachse, M., Morales, M., Martin-Folgar, R., Liste, I., & Cañas-Portilla, A. I. (2024). Internalization and toxicity of polystyrene nanoplastics on inmortalized human neural stem cells. Chemosphere, 355, 141815.
DOINeurotoxicity and endocrine disruption caused by polystyrene nanoparticles in zebrafish embryo.
9. Torres-Ruiz, M., de Alba González, M., Morales, M., Martin-Folgar, R., González, M. C., Cañas-Portilla, A. I., & De la Vieja, A. (2023). Neurotoxicity and endocrine disruption caused by polystyrene nanoparticles in zebrafish embryo. Science of The Total Environment, 874, 162406.
DOIMethylmercury Risk Assessment Based on European Human Biomonitoring Data.
5. Domínguez-Morueco, N., Pedraza-Díaz, S., González-Caballero, M. del C., Esteban-López, M., de Alba-González, M., Katsonouri, A., Santonen, T., Cañas-Portilla, A., & Castaño, A. (2022). Methylmercury Risk Assessment Based on European Human Biomonitoring Data. Toxics, 10(8), 427.
DOIPollution, indoor air.
6. González-Caballero, M. del Carmen, de Alba-Gonzalez, M., & Tarazona, J. V. (2024). Pollution, indoor air. Encyclopedia of Toxicology, Fourth Edition: Volume 1-9, 7, 787–799.
DOIHuman neural stem cells in developmental neurotoxicology: Current scenario and future prospects.
10. Rosca, A., Coronel, R., López-Alonso, V., Liste, I., & González-Caballero, M. C. (2023). Human neural stem cells in developmental neurotoxicology: Current scenario and future prospects. Advances in Neurotoxicology, 9, 197–237.
DOIHow to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU.
3. Santonen, T., Mahiout, S., Alvito, P., Apel, P., Bessems, J., Bil, W., Borges, T., Bose-O’Reilly, S., Buekers, J., Cañas Portilla, A. I., Calvo, A. C., de Alba González, M., Domínguez-Morueco, N., López, M. E., Falnoga, I., Gerofke, A., Caballero, M. del C. G., Horvat, M., Huuskonen, P., … Schoeters, G. (2023). How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU. International Journal of Hygiene and Environmental Health, 249, 114139.
DOIA Tiered Approach for Assessing Individual and Combined Risk of Pyrethroids Using Human Biomonitoring Data.
1. Tarazona, J. V., Cattaneo, I., Niemann, L., Pedraza-Diaz, S., González-Caballero, M. C., de Alba-Gonzalez, M., Cañas, A., Dominguez-Morueco, N., Esteban-López, M., Castaño, A., Borges, T., Katsonouri, A., Makris, K. C., Ottenbros, I., Mol, H., De Decker, A., Morrens, B., Berman, T., Barnett-Itzhaki, Z., … Santonen, T. (2022). A Tiered Approach for Assessing Individual and Combined Risk of Pyrethroids Using Human Biomonitoring Data. Toxics 2022, Vol. 10, Page 451, 10(8), 451.
DOIInformación adicional
Nuestro objetivo principal es estudiar las interacciones entre determinados factores genéticos y medioambientales, como son las proteínas Ras y los contaminantes ambientales, como factores de riesgo en los trastornos del neurodesarrollo.
Para ello, emplearemos varias aproximaciones metodológicas, desde la biología molecular y celular a la electrofisiología, la histología y el estudio de la conducta animal.
Nuestra hipótesis es que las condiciones genéticas que favorecen la activación basal de la vía Ras-MAPK (como es el caso de las rasopatías) pueden tener una mayor susceptibilidad a la exposición a contaminantes ambientales.