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Investigación
Interacciones genético-ambientales en los trastornos del neurodesarrollo
Líneas de investigación
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Interacciones genético-ambientales en los trastornos del neurodesarrollo
- Modelos celulares in vitro y ex vivo de rasopatías, tales como células madre pluripotenciales, células madre neurales, cultivos primarios neuronales y cultivos organotípicos de rodajas de hipocampo, para estudiar el neurodesarrollo.
- Modelos animales de ratón con mutaciones en las proteínas Ras asociadas a los trastornos de neurodesarrollo (rasopatías) para estudiar la conducta animal relacionada con dichos trastornos, como el desarrollo motor, el comportamiento social y las habilidades cognitivas como la memoria y el aprendizaje.
Proyectos de investigación
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2024-2027 Ministerio de Ciencia e Innovación, Generación de conocimiento, PID2022-136932OB-I00, “Interacciones genético-ambientales como factor de riesgo en la disfunción sináptica asociada a las rasopatías”. IP: Victor Briz (ISCIII). Financiación: 162.500€.
2023-2028 Ministerio de Ciencia e Innovación, Ayuda Ramón y Cajal, RYC2021-031395-I, “Gene-environment interactions as risk factor for neurodevelopmental and cognitive disorders”. IP: Victor Briz (ISCIII). Financiación: 236.350€.
Publicaciones destacadas
Effects of 700 and 3500 MHz 5G radiofrequency exposure on developing zebrafish embryos.
Torres-Ruiz, M.; Suárez, O. J.; López, V.; Marina, P.; Sanchis, A.; Liste, I.; De Alba, M.; Ramos, V., Effects of 700 and 3500 MHz 5G radiofrequency exposure on developing zebrafish embryos. Sci Total Environ 2024, 915, 169475.
DOIA methodological framework for estimating ambient PM2.5 particulate matter concentrations in the UK. Journal of Environmental Sciences, 150, 676-691. Q1
David Galán-Madruga, Parya Broomandi, Alfredo Satyanaga, Ali Jahanbakhsi, Mehdi Bagheri, et al (2025).
DOIDifferent Ras isoforms regulate synaptic plasticity in opposite directions
López-Merino E, Fernández-Rodrigo A, Jiang JG, Gutiérrez-Eisman S, Fernández de Sevilla D, Fernández-Medarde A, Santos E, Guerra C, Barbacid M, Esteban JA, Briz V. EMBO J. 2025 Feb 21.
DOIInvestigation of Zebrafish Embryo Membranes at Epiboly Stage through Electrorotation Technique
Sanchis-Otero, A.; Reina-Maldonado, M. T.; Roldán, J.; Barragán, V. M.; Muñoz, S., Investigation of Zebrafish Embryo Membranes at Epiboly Stage through Electrorotation Technique. Membranes (Basel) 2023, 13 (9).
DOIA chemically functionalized glass support for gold and silver metallic nanoparticle analysis with LIBS
J. Cárdenas-Escudero, V. Gardette, A. Villalonga, A. Sánchez, R. Villalonga, V. Motto-Ros, D. Galán-Madruga and J. O. Cáceres (2024). A chemically functionalized glass support for gold and silver metallic nanoparticle analysis with LIBS. Journal of Analytical Atomic Spectrometry, 39. 962. Q1
DOIEnhanced mGluR5 intracellular activity causes psychiatric alterations in Niemann Pick type C disease
Ana Toledano-Zaragoza, Violeta Enriquez-Zarralanga, Sara Naya-Forcano, Víctor Briz, Rocío Alfaro-Ruíz, Miguel Parra-Martínez, Daniel N. Mitroi, Rafael Luján, José A. Esteban & María Dolores Ledesma. Enhanced mGluR5 intracellular activity causes psychiatric alterations in Niemann Pick type C disease. Cell Death and Disease (2024) 15:771.
DOIAn Electromagnetic Study of the Impact of Brain Anatomy on Deep Brain Stimulation.
Muñoz S, García-Prieto J, Bajo R., Antoranz P., Ronda S., Barragán V.M., Jiménez J.C., Sanchis A., An Electromagnetic Study of the Impact of Brain Anatomy on Deep Brain Stimulation. Acta Scientific MEDICAL SCIENCES 2023, 7.
DOILung Function and Symptoms of Exposure to the Volcanic Eruption in the Canary Islands: First Follow-Up of the ASHES Study.
Saraga D, T. Maggos, C. Degrendele, J. Klánová, M. Horvat, D. Kocman, T. Kanduč, S. Garcia Dos Santos, R. Franco, P. Morillo Gómez, M. Manousakas, K. Bairachtari, K. Eleftheriadis, M. Kermenidou, S. Karakitsios, A. Gotti and D. Sarigiannis (2021). Multi-city comparative PM2.5 source apportionment for fifteen sites in Europe: The ICARUS project. Science of Total Environment 751, 141855. FI: 6,551.
DOIFunctional specialization of different PI3K isoforms for the control of neuronal architecture, synaptic plasticity, and cognition
Sánchez-Castillo C, Cuartero MI, Fernández-Rodrigo A, Briz V, López-García S, Jiménez-Sánchez R, López JA, Graupera M, Esteban JA. Molecular specialization of PI3K isoforms for the control of neuronal architecture, synaptic plasticity and cognition. Sci Adv. 2022 Nov 25;8(47):eabq8109.
DOIToxicity assessment of biological suspensions using the dielectric impedance spectroscopy technique.
Muñoz, S.; Sebastián, J. L.; Antoranz, P.; García-Cambero, J. P.; Sanchis-Otero, A., Toxicity assessment of biological suspensions using the dielectric impedance spectroscopy technique. International Journal of Radiation Biology 2018, 1-7.
DOIEvaluating urban indoor and outdoor PM10-bound organochlorine pesticides. Air quality status and health impact
Galán-Madruga D, Cárdenas-Escudero J, Broomandi P, Cáceres J.O., and González-Caballero MC (2022). Evaluating urban indoor and outdoor PM10-bound organochlorine pesticides. Air quality status and health impact. Building and Environment. D1. FI: 7.093
DOIPerinatal exposure to pesticides alters synaptic plasticity signaling and induces behavioral deficits associated with neurodevelopmental disorders
López-Merino E, Cuartero MI, Esteban JA, Briz V. Perinatal exposure to pesticides alters synaptic plasticity signaling and induces behavioral deficits associated with neurodevelopmental disorders. Cell Biol Toxicol. 2022 Feb 8.
PUBMEDDielectric characterization of the yeast cell budding cycle
Sebastián Franco, J. L.; Sanchis-Otero, A.; Roldán Madroñero, J.; Muñoz San Martin, S., Dielectric characterization of the yeast cell budding cycle. Progress in Electromagnetics Research 2012, 134.
DOIIntegrating dual C and N isotopic approach to elemental and mathematical solutions for improving the PM source apportionment in complex urban and industrial cities: Case of Tarragona – Spain
Edson Plasencia Sánchez, Francisco Sánchez-Soberon, Joaquim Rovira, Jordi Sierra, Marta Schuhmacher, Albert Soler, Clara Torrentó, Mónica Rosell (2023). Integrating dual C and N isotopic approach to elemental and mathematical solutions for improving the PM source apportionment in complex urban and industrial cities: Case of Tarragona – Spain. Atmospheric Environment 293, 119449. Q2
DOIControl of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly
Conde-Dusman MJ, Dey PN, Elía-Zudaire Ó, Rabaneda LG, García-Lira C, Grand T, Briz V, Velasco ER, Andero R, Niñerola S, Barco A, Paoletti P, Wesseling JF, Gardoni F, Tavalin SJ, Perez-Otaño I. Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly. eLife 2021, 10, e71575.
DOIUrban air quality changes resulting from the lockdown period due to the COVID‑19 pandemic.
David Galán-Madruga (2023). Urban air quality changes resulting from the lockdown period due to the COVID‑19 pandemic. International Journal of Environmental Science and Technology, 20, 7083–7098. Q3
DOIAlpha2-Containing Glycine Receptors Promote Neonatal Spontaneous Activity of Striatal Medium Spiny Neurons and Support Maturation of Glutamatergic Inputs
Comhair J, Devoght J, Morelli G, Harvey RJ, Briz V, Borrie SC, Bagni C, Rigo JM, Schiffmann SN, Gall D, Brône B, Molchanova SM. Alpha2-Containing Glycine Receptors Promote Neonatal Spontaneous Activity of Striatal Medium Spiny Neurons and Support Maturation of Glutamatergic Inputs. Front Mol Neurosci. 2018 Oct 15;11:380. doi: 10.3389/fnmol.2018.00380.
DOIHelping WWTP managers to address the volatile methylsiloxanes issue–Behaviour and complete mass balance in a conventional plant
Francisco Sanchez-Soberón, Gabriel F. Pantuzza, Madalena Fernandes, Vera Homem, Arminda Alves, Milton Fontes, Magda André, Joana Cunha, Nuno Ratola (2023). Helping WWTP managers to address the volatile methylsiloxanes issue–Behaviour and complete mass balance in a conventional plant. Environmental Research 234, 116564. Q1
DOIThe non-coding RNA BC1 regulates experience-dependent structural plasticity and learning
Briz V, Restivo L, Pasciuto E, Juczewski K, Mercaldo V, Lo AC, Baatsen P, Gounko NV, Borreca A, Girardi T, Luca R, Nys J, Poorthuis RB, Mansvelder HD, Fisone G, Ammassari-Teule M, Arckens L, Krieger P, Meredith R, Bagni C. The non-coding RNA BC1 regulates experience-dependent structural plasticity and learning. Nat Commun. 2017 Aug 17;8(1):293.
DOIHealth risk assessment of the European inhabitants exposed to contaminated ambient particulate matter by potentially toxic elements
Parya Broomandi, Andrés Rodríguez-Seijo, Nasime Janatian, Aram Fathian, Aidana Tleuken, Kaveh Mohammadpour, David Galán-Madruga, et al. (2023). Health risk assessment of the European inhabitants exposed to contaminated ambient particulate matter by potentially toxic elements. Environmental Pollution, 323, 121232. Q1
DOIInformación adicional
Nuestro objetivo principal es estudiar las interacciones entre determinados factores genéticos y medioambientales, como son las proteínas Ras y los contaminantes ambientales, como factores de riesgo en los trastornos del neurodesarrollo.
Para ello, emplearemos varias aproximaciones metodológicas, desde la biología molecular y celular a la electrofisiología, la histología y el estudio de la conducta animal.
Nuestra hipótesis es que las condiciones genéticas que favorecen la activación basal de la vía Ras-MAPK (como es el caso de las rasopatías) pueden tener una mayor susceptibilidad a la exposición a contaminantes ambientales.